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Objective:To investigate the effect and influencing factors of anti-retroviral therapy (ART) in human immunodeficiency virus (HIV)-positive female commercial sex workers (CSW) in Guangxi Zhuang Autonomous Region.Methods:A retrospective cohort study was used in this study. A total of 661 HIV-positive CSW receiving ART from the Guangxi Zhuang Autonomous Region′s municipal and county-level Centers for Disease Control and Prevention (CDC) reported to Guangxi Zhuang Autonomous Region CDC from January 1, 2009 to December 31, 2018 were included.The demographic information of the patients, marital status, past medical history, acquired immunodeficiency syndrome (AIDS)-related diseases after six to 12 months of ART, medications, CD4 + T lymphocytes, virological and immunological effects after receiving ART for six to 12 months were collected. Logistic regression model was used to analyze the influencing factors of virological failure and immunological failure of HIV-positive CSW after six to 12 months of ART. Results:Among 661 HIV-positive CSW, 50(7.6%) cases experienced virological failure, 80(12.1%) cases experienced immunological failure, and 13(2.0%) had both virological failure and immunological failure.There were 85 cases (12.9%) who had a history of sexually transmitted diseases. Multivariate logistic regression analysis showed that unmarried (adjusted odds ratio (a OR)=3.298, 95% confidence interval ( CI) 1.285 to 8.461), AIDS-related diseases after six to 12 months of ART (a OR=4.391, 95% CI 1.555 to 12.402) and missed medications in the last seven days (a OR=3.731, 95% CI 1.942 to 7.166) were risk factors for virological failure. Compared with CD4 + T lymphocytes<200.00/μL at baseline, 350.00≤CD4 + T lymphocytes <500.00/μL (a OR=3.543, 95% CI 1.631 to 7.701) and CD4 + T lymphocytes≥500.00/μL (a OR=2.358, 95% CI 1.002 to 5.547) were risk factors for immunological failure. Conclusions:HIV-positive CSW in Guangxi Zhuang Autonomous Region have a better treatment effect, with low rates of virological failure and immunological failure. Marital status, baseline CD4 + T lymphocyte counts, AIDS-related diseases after six to 12 months of ART, and missed medication in the last seven days are factors influencing the effect of six to 12 months of ART.
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Objective To investigate the changes of proportion on both consistent condom use and syphilis infection among low-fee female sex workers aged 35 and above (LFSW),in order to provide evidence for targeted intervention strategies.Methods A total of six cities-Liuzhou city and Pingnan couty of Guigang city of Guangxi Zhuang Autonomous Region,Jinghong city of Xishuangbanna Dai autonomous prefecture and Dali city of Dali Bai autonomous prefecture of Yunnan province,Zhangjiajie city and Jianghua Yao autonomous county of Yongzhou city Hunan province were involved in this study,with 60 eligible participants needed in each city,estimated through a pre-study.The first cross-sectional survey was completed from October 2012 to January 2013.Face-to-face questionnaire interview was carried out to collect information on socio-demography,work-related information and condom use situation.Blood was collected for syphilis testing.The second cross-sectional survey was carried out from June to September,2015 under the same procedure.Results A total of 371 and 403 eligible participants were included in the first and second survey,respectively.When comparing the two surveys,we noticed that the average age showed a slight change,from 42.4 years to 43.8 years old (t=3.537,P＜0.001) and the average price for every commercial sex exchange increased from 36.8 RMB to 49.5 RMB (t=11.961,P＜0.001).In the first survey,46.9％ (174/371) of the participants had more than two years of experience working as LFSW,compared to 61.3％ (247/403) in the second survcy (x2=16.125,P＜0.001).Also,46.9％ (174/371) of the participants consistently used condoms with clients in the past month in the first survey versus 64.3％ (259/403) (x2=23.641,P＜0.001) in the second one.Rates of syphilis infection were found from 15.9％ (59/371) in the first survey reduced to 7.2％ (29/403) in the second survey (x2=14.533,P＜0.001).Conclusion Compared with the first survey,the proportion of consistent condoms use showed an increase.Although the proportion of syphilis infection decreased in the second survey,the scope did not meet the criteria on syphilis,set by the government.Targeted intervention strategies on condom promotion and syphilis control should be implemented consistently in this population.
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Objective To investigate the changes of proportion on both consistent condom use and syphilis infection among low-fee female sex workers aged 35 and above (LFSW),in order to provide evidence for targeted intervention strategies.Methods A total of six cities-Liuzhou city and Pingnan couty of Guigang city of Guangxi Zhuang Autonomous Region,Jinghong city of Xishuangbanna Dai autonomous prefecture and Dali city of Dali Bai autonomous prefecture of Yunnan province,Zhangjiajie city and Jianghua Yao autonomous county of Yongzhou city Hunan province were involved in this study,with 60 eligible participants needed in each city,estimated through a pre-study.The first cross-sectional survey was completed from October 2012 to January 2013.Face-to-face questionnaire interview was carried out to collect information on socio-demography,work-related information and condom use situation.Blood was collected for syphilis testing.The second cross-sectional survey was carried out from June to September,2015 under the same procedure.Results A total of 371 and 403 eligible participants were included in the first and second survey,respectively.When comparing the two surveys,we noticed that the average age showed a slight change,from 42.4 years to 43.8 years old (t=3.537,P＜0.001) and the average price for every commercial sex exchange increased from 36.8 RMB to 49.5 RMB (t=11.961,P＜0.001).In the first survey,46.9％ (174/371) of the participants had more than two years of experience working as LFSW,compared to 61.3％ (247/403) in the second survcy (x2=16.125,P＜0.001).Also,46.9％ (174/371) of the participants consistently used condoms with clients in the past month in the first survey versus 64.3％ (259/403) (x2=23.641,P＜0.001) in the second one.Rates of syphilis infection were found from 15.9％ (59/371) in the first survey reduced to 7.2％ (29/403) in the second survey (x2=14.533,P＜0.001).Conclusion Compared with the first survey,the proportion of consistent condoms use showed an increase.Although the proportion of syphilis infection decreased in the second survey,the scope did not meet the criteria on syphilis,set by the government.Targeted intervention strategies on condom promotion and syphilis control should be implemented consistently in this population.
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Objective To analyze the data of TB/HIV dual infection screening and treatment monitoring in Guangxi during 2010-2015 and to evaluate the prevention and treatment status quo and development trend.Methods The annual monitoring report forms of TB/HIV dual infection during 2010-2015 were collected for deriving the special data of AIDS in corresponding years.Then the data were conducted the comparison and trend analysis.Results The acceptance rates of HIV detection among Guangxi TB patients and the acceptance rate of TB related screening detection in patients with HIV infection/AIDS showed the increasing trend year by year (P＜0.05);the positive detection rate of two-way showed the decreasing trend year by year (P＜0.05).The patients with TB/HIV dual infection were mainly concentrated in the central area of Guangxi.The annual monitoring report table data in annual monitoring TB/HIV dual infection prevention and treatment work trended to be consistent with the twoway registration and screening data in the special report system,but the errors still existed;the rate of receiving anti-TB and anti-viral combined therapy in the patients with TB/HIV dual infection was lower,which was fluctuated from 20％ to 60％;the treatment success rate was still elevated year by year,but which was affected by death,lose and other outcomes.Conclusion The TB/HIV dual epidemic situation has already obtained a certain effect along with comprehensively promoting the dual infection prevention and control work in Guangxi area.
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<p><b>OBJECTIVE</b>To understand the efficacy of antiviral therapy on prevention of HIV transmission and to assess the feasibility of treatment-as-prevention strategy in public health practice, among sero-discordant couples in Guangxi Zhuang autonomous region (Guangxi).</p><p><b>METHODS</b>Data was gathered through the AIDS prevention and control information system in Guangxi from January 1, 2008 to December 31, 2014, on HIV sero-discordant couples. Time-dependent Cox Model was used to analyze the efficacy of antiviral treatment.</p><p><b>RESULTS</b>A total of 7 694 sero-discordant couples were followed and 394 appeared positive from those negative spouses. The overall HIV positive seroconversion rate was 2.5 (2.2-2.7) /100 person-year. The HIV positive sero-conversion rates were 4.3 (3.7-4.8) /100 person-year in the untreated cohort and 1.6 (1.4-1.9) per 100 person-year in the treated cohort. Rate of HIV transmission declined by 51% in the treated cohort (HR=0.49, 95%CI: 0.40-0.60) but appeared as 45% (AHR=0.55, 95%CI:0.43-0.69) after adjusting for factors as sex, age, education, marital status, occupation, transmission route and baseline CD4(+)T lymphocyte cell count. The rate of reduction in transmission was significant among couples in which the HIV-positive spouses showing the following features as: aged ≥25 years, married, farmers, with educational level of junior high school or below, baseline CD4(+)T lymphocyte cell count <500 cells/mm(3) and infection was through heterosexual intercourse.</p><p><b>CONCLUSION</b>Antiviral therapy as a prevention strategy among sero-discordant couples seemed feasible and effective in Guangxi. Expansion of the coverage on antiviral therapy would reduce the spread of HIV in married couples.</p>